Specific sorbent for the solid phase extraction of Tamoxifen from biological matrices
Tamoxifen is a drug that interferes with the activity of estrogen. It has been used for more than 30 years to treat and to prevent breast cancer.
In addition, since January 2000, Tamoxifen has been included in the list of prohibited substances by the International Olympic Committee. So, the presence of these compounds in urine is a doping proof. The analysis of complex samples, like biofluids, requires a sample preparation step prior to analysis.
AFFINIMIP® SPE Tamoxifen are selective solid phase extraction cartridges that selectively clean and concentrate Tamoxifen and its metabolites prior to analysis by HPLC.
Benefits
- Ready for use and optimized extraction protocols adapted for each tested matrices
- Perfect clean-up system for trace analysis
- Unambiguous and reliable analysis
- Concentration of the analyte and its metabolites
HPLC comparison of urine sample spiked with tamoxifen and 4-OH Tamoxifen (its main metabolite) after extraction through HLB and AFFINIMIP® SPE Tamoxifen.
Product Information
- Tested matrices : Extraction methodologies for Tamoxifen from urine.
- Other matrices : contact us
- Protocol :
- Loading : Urine
- Washing : Water- Methanol
- Elution : Methanol - Acetic acid
- Detection : HPLC-UV
- Format : 3mL cartridges
- Particle diameter range : 25-80 µm
- Stability : 3 years
- Shipping & Storage : Ambient temperature
- Catalog number : PH101-02 for 25 columns
PH101-03 for 50 columns
For more information
Interest of molecularly imprinted polymers in the fight against doping. Extraction of tamoxifen and its main metabolite from urine followed by high-performance liquid chromatography with UV detection. J. Chromatography A, 1196-1197, 81-88, 2008.
Publication
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