BPA is also an endocrine disruptor, which can mimic the body's own hormones and may lead to negative health effects. The migration of BPA from the packaging to food is the main source of consumers' exposure to BPA. So, the European commission has defined a specific migration limit at a maximum level of 0.6 mg of BPA/kg of food (Directive 2011/8/EU of 28 January 2011). In addition, the directive prohibits the use of BPA to manufacture infant feeding bottles.
AFFINIMIP® SPE Bisphenol A are selective solid phase extraction cartridges that selectively clean and concentrate Bisphenol A prior to analysis by chromatography (LC, GC...).

Fluorescence profile of 3mL babymilk (λ exc/em: 230-315nm) spiked at 10 ng/mL with Bisphenol A before cleanup (red) and after cleanup with AFFINIMIP® SPE Bisphenol A (blue), and spiked at 173ng/mL after cleanup (pink).
This study describes the solid phase extraction of Bisphenol A from beer at low concentrations (1 and 2µg/L) using AFFINIMIP® SPE Bisphenol A. HPLC analysis was performed with a flurescence detector. The results demonstrate the efficiency of the clean-up: high recovery yield (> 90%), a good repeatability and reproducibility were obtained.
Application Note AFFINIMIP® SPE for the analysis of Bisphenol A in Beer at low concentrations
We demonstrate in this application note that a reliable quantification of Bisphenol A in liquid infant formula using fluorescence detection is possible, even at low concentrations(1 and 2µg/L). The use of AFFINIMIP® SPE Bisphenol A enables to eliminate the tedious derivatization step required by gas chromatography.
The tests were performed in canned peas and carrots and canned tuna and salmon. The results demonstrate the efficiency of the clean-up with fluorescence detection: high recovery yield (> 95%), a good repeatability and reproducibility were obtained in all the matrices.This method is also perfectly suitable for clean-up before GC-MS/MS or LC-MS/MS.